Structure and function converge to identify a hydrogen bond in a group I ribozyme active site.
نویسندگان
چکیده
Marcello Forconi[+], Department of Biochemistry, Beckman Center, B400, Stanford University, Stanford, CA 94305-5307 (USA), Fax: (+1) 650-723-6783, Homepage: http://cmgm.stanford.edu/biochem/herschlag/ Raghuvir N. Sengupta[+], Department of Biochemistry and Molecular Biology, Department of Chemistry, and Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, CIS W406, Chicago IL 60637 (USA), Fax: (+1) 773-702-0271
منابع مشابه
A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site.
Protein enzymes appear to use extensive packing and hydrogen bonding interactions to precisely position catalytic groups within active sites. Because of their inherent backbone flexibility and limited side chain repertoire, RNA enzymes face additional challenges relative to proteins in precisely positioning substrates and catalytic groups. Here, we use the group I ribozyme to probe the existenc...
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عنوان ژورنال:
- Angewandte Chemie
دوره 48 39 شماره
صفحات -
تاریخ انتشار 2009